After an in-depth review of Vortioxetine, I've found it to be generally safe and well-tolerated. Common side effects include nausea and vomiting, but these are typically mild and temporary. Despite these side effects, Vortioxetine still stands as a beneficial treatment option for major depressive disorder. It's crucial, though, to monitor patients under this medication, given that responses can vary. Overall, Vortioxetine provides a balance of efficacy and tolerability that is essential in the treatment of depression.